Autoantibodies neutralizing type I IFNs underlie severe tick-borne encephalitis in ∼10% of patients.
Gervais A,Marchal A,Fortova A,Berankova M,Krbkova L,Pychova M,Salat J,Zhao S,Kerrouche N,Le Voyer T,Stiasny K,Raffl S,Schieber Pachart A,Fafi-Kremer S,Gravier S,Robbiani D,Abel L,MacDonald M,Rice C,Weissmann G,Kamal Eldin T,Robatscher E,Erne E,Pagani E,Borghesi A,Puel A,Bastard P,Velay A,Martinot M,Hansmann Y,Aberle J,Ruzek D,Cobat A,Zhang S,Casanova J
Source :
2024 Sep 24
Pmid / DOI:
39316018
Abstract
Tick-borne encephalitis (TBE) virus (TBEV) is transmitted to humans via tick bites. Infection is benign in >90% of the cases but can cause mild (