Enteropathy-associated T-cell lymphoma complicating an autoimmune enteropathy.
Malamut G,Verkarre V,Callens C,Colussi O,Rahmi G,MacIntyre E,Haïoun C,Meresse B,Brousse N,Romana S,Hermine O,Cerf-Bensussan N,Cellier C
Source :
2012 Jan 4
Pmid / DOI:
22226659
Abstract
Enteropathy-associated T-cell lymphoma (EATL) is a rare non-Hodgkin lymphoma frequently associated with celiac disease. We report a case of EATL complicating adult autoimmune enteropathy (AIE). Analysis of phenotype, rearrangements in T-cell receptor genes, and chromosome alterations by high-resolution comparative genomic hybridization identified features distinct from those described for types I and II EATL. Furthermore, EATL arose from a single T-cell clone that had been present for several years in AIE-associated, oligoclonal, intestinal T-cell infiltrate. Emerging T-cell clones should be monitored in patients with AIE who receive long-term immunosuppressive therapy.Copyright © 2012 AGA Institute. Published by Elsevier Inc. All rights reserved.