High Nasopharyngeal SARS-CoV-2 Load and Delayed Clearance in Hospitalized Patients With Blood Autoantibodies Neutralizing Type I Interferons.
Marchal A,Kerdiles T,Perrin A,Gervais A,Bastard P,Bizien L,Lingas G,Massonnaud C,Bouscambert-Duchamp M,Gaymard A,Peiffer-Smadja N,Mentre F,Guedj J,Abel L,Casanova J,Puel A,Hites M,Ader F,Bertrand J,Cobat A
Source :
2026 Avr 29
Pmid / DOI:
42053985
Abstract
Autoantibodies neutralizing type I interferon (AAN-I-IFNs) underlie life-threatening COVID-19. In hospitalized COVID-19 patients of the DisCoVeRy trial (NCT-04315948), AAN-I-IFNs were associated with higher nasopharyngeal viral load at inclusion (P = 1.4 × 10-3) and delayed viral clearance (P = .013). Blood AAN-I-IFNs, high viral load and delayed clearance were also independent risk factors for critical COVID-19.KEYWORDSSARS-CoV-2, anti-type I interferon autoantibodies, viral load© The Author(s) 2026. Published by Oxford University Press on behalf of Infectious Diseases Society of America.