Serological diagnosis of chronic skin granulomas caused by wild-type or vaccine-derived rubella virus in patients with inherited HLA class I deficiency.
Luciani L,Darazam I,Nougairède A,Robert S,Momenilandi M,Rosain J,Bustamante J,Deswarte C,Adamski H,Picard-Dahan C,Mansouri N,Piorkowski G,Cortes A,Placidi C,Descamps V,Suarez F,Casanova J,Mansouri D,de Lamballerie X,Béziat V
Source :
2025 Jul 23
Pmid / DOI:
41531537
Abstract
Patients with TAP1/TAP2 deficiency develop rubella-associated skin granulomas due to impaired HLA-I antigen presentation. Markedly elevated rubella IgG levels may support diagnosis when PCR is unavailable. These findings also underscore the specific vulnerability of such patients to live-attenuated rubella vaccination.KEYWORDSHLA-I, Human leukocyte antigen (HLA) class 1, Rubella, TAP1, TAP2, bare lymphocytes syndrome