Shared genetic predisposition in rheumatoid arthritis-interstitial lung disease and familial pulmonary fibrosis.
Juge P,Borie R,Kannengiesser C,Gazal S,Revy P,Wemeau-Stervinou L,Debray M,Ottaviani S,Marchand-Adam S,Nathan N,Thabut G,Richez C,Nunes H,Callebaut I,Justet A,Leulliot N,Bonnefond A,Salgado D,Richette P,Desvignes J,Lioté H,Froguel P,Allanore Y,Sand O,Dromer C,Flipo R,Clément A,Béroud C,Sibilia J,Coustet B,Cottin V,Boissier M,Wallaert B,Schaeverbeke T,Dastot le Moal F,Frazier A,Ménard C,Soubrier M,Saidenberg N,Valeyre D,Amselem S,Boileau C,Crestani B,Dieudé P
Source :
2017 May 11
Pmid / DOI:
28495692
Abstract
Despite its high prevalence and mortality, little is known about the pathogenesis of rheumatoid arthritis-associated interstitial lung disease (RA-ILD). Given that familial pulmonary fibrosis (FPF) and RA-ILD frequently share the usual pattern of interstitial pneumonia and common environmental risk factors, we hypothesised that the two diseases might share additional risk factors, including FPF-linked genes. Our aim was to identify coding mutations of FPF-risk genes associated with RA-ILD.We used whole exome sequencing (WES), followed by restricted analysis of a discrete number of FPF-linked genes and performed a burden test to assess the excess number of mutations in RA-ILD patients compared to controls.Among the 101 RA-ILD patients included, 12 (11.9%) had 13 WES-identified heterozygous mutations in the , , or coding regions The burden test, based on 81 RA-ILD patients and 1010 controls of European ancestry, revealed an excess of , , or mutations in RA-ILD patients (OR 3.17, 95% CI 1.53-6.12; p=9.45×10). Telomeres were shorter in RA-ILD patients with a , or mutation than in controls (p=2.87×10).Our results support the contribution of FPF-linked genes to RA-ILD susceptibility.Copyright ©ERS 2017.