Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia.
Zhang Q,Matuozzo D,Le Pen J,Lee D,Moens L,Asano T,Bohlen J,Liu Z,Moncada-Velez M,Kendir-Demirkol Y,Jing H,Bizien L,Marchal A,Abolhassani H,Delafontaine S,Bucciol G,Bayhan G,Keles S,Kiykim A,Hancerli S,Haerynck F,Florkin B,Hatipoglu N,Ozcelik T,Morelle G,Zatz M,Ng L,Lye D,Young B,Leo Y,Dalgard C,Lifton R,Renia L,Meyts I,Jouanguy E,Hammarström L,Pan-Hammarström Q,Boisson B,Bastard P,Su H,Boisson-Dupuis S,Abel L,Rice C,Zhang S,Cobat A,Casanova J
Source :
2022 Jun 16
Pmid / DOI:
35708626
Abstract
Recessive or dominant inborn errors of type I interferon (IFN) immunity can underlie critical COVID-19 pneumonia in unvaccinated adults. The risk of COVID-19 pneumonia in unvaccinated children, which is much lower than in unvaccinated adults, remains unexplained. In an international cohort of 112 children (