Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children.

Bastard P,Gervais A,Taniguchi M,Saare L,Särekannu K,Le Voyer T,Philippot Q,Rosain J,Bizien L,Asano T,Garcia-Prat M,Parra-Martínez A,Migaud M,Tsumura M,Conti F,Belot A,Rivière J,Morio T,Tanaka J,Javouhey E,Haerynck F,Duvlis S,Ozcelik T,Keles S,Tandjaoui-Lambiotte Y,Escoda S,Husain M,Pan-Hammarström Q,Hammarström L,Ahlijah G,Abi Haidar A,Soudee C,Arseguel V,Abolhassani H,Sahanic S,Tancevski I,Nukui Y,Hayakawa S,Chrousos G,Michos A,Tatsi E,Filippatos F,Rodriguez-Palmero A,Troya J,Tipu I,Meyts I,Roussel L,Ostrowski S,Schidlowski L,Prando C,Condino-Neto A,Cheikh N,Bousfiha A,El Bakkouri J,Peterson P,Pujol A,Lévy R,Quartier P,Vinh D,Boisson B,Béziat V,Zhang S,Borghesi A,Pession A,Andreakos E,Marr N,Mentis A,Mogensen T,Rodríguez-Gallego C,Soler-Palacin P,Colobran R,Tillmann V,Neven B,Trouillet-Assant S,Brodin P,Abel L,Jouanguy E,Zhang Q,Martinón-Torres F,Salas A,Gómez-Carballa A,Gonzalez-Granado L,Kisand K,Okada S,Puel A,Cobat A,Casanova J

Source :

2024 Jan 4

Pmid / DOI:

38175961

Abstract

We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only in three, IFN-α2 plus IFN-ω in five, and IFN-α2, IFN-ω plus IFN-β in two; IFN-ω only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-α2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-ω in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-α2 only (OR [95% CI] = 67.6 [5.7-9,196.6]) than for auto-Abs neutralizing IFN-ω only (OR [95% CI] = 2.6 [1.2-5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6-35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1-9.6]) of IFN-ω and/or IFN-α2.© 2024 Bastard et al.

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