chef d'équipe | Gaël Ménasché et Fernando Sepulveda
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Gaël Ménasché received her Ph.D. from the University Pierre et Marie Curie, Paris (France) under the direction of Dr. Geneviève de Saint Basile at the Necker-Enfants malades hospital in 2004. Then, she performed her postdoctoral training in the Gary Koretzky’s lab in Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia (USA). In 2007, she joined INSERM at Imagine institute in Paris. Gaël Ménasché’s research has been focusing on molecular mechanisms underlying genetic immune disorders affecting immune homeostasis and the molecular dissection of the cytotoxic activity in lymphocytes through the study of primary hemophagocytic syndromes. This work has led to the identification of several key molecules regulating the trafficking and the docking steps of lytic granules. Based on this expertise, Gael Ménasché has progressively focused her research on regulated secretion processes and vesicular trafficking in immune cells and the genetic bases of severe allergic disorders.
Research: a scientific adventure
Our goal: to better understand genetic diseases to better treat them.