Alain HOVNANIAN | Institut Imagine

Présentation

Alain HOVNANIAN

Maladies génétiques de la peau : du mécanisme de la maladie à la thérapie

Contact :

01 42 75 42 89

alain.hovnanian@inserm.fr

À propos

Publications scientifiques

Publications

2026

ADAR1 loss-of-function variants altering RNA editing define a new interferon-..., Rockefeller University Press
2024

Novel variants impairing Sp1 transcription factor binding in the COL7A1 promo..., Eur J Hum Genet
2024

Splice modulation strategy applied to deep intronic variants in causing rece..., Proc Natl Acad Sci U S A
2024

Citrullinated Histone H3, a Marker for Neutrophil Extracellular Traps, Is Ass..., Cancers (Basel)
2024

Highly Efficient Ex Vivo Correction of COL7A1 through Ribonucleoprotein-Based..., Elsevier BV
2024

Individuals with JAK1 variants are affected by syndromic features encompassin..., J Exp Med
2023

Pachyonychia Congenita: A Research Agenda Leading to New Therapeutic Approaches., J Invest Dermatol
2023

Generation and characterization of induced pluripotent stem cell lines from t..., Elsevier BV
2021

Drug Repurposing Reveals mTOR Inhibition as a Promising Strategy for Epidermo..., J Invest Dermatol
2021

Dystrophic epidermolysis bullosa pruriginosa: a new case series of a rare phe..., J Eur Acad Dermatol Venereol
2021

Netherton syndrome subtypes share IL-17/IL-36 signature with distinct IFN-α a..., J Allergy Clin Immunol
2021

Humans with inherited T cell CD28 deficiency are susceptible to skin papillom..., Cell
2021

Diagnosis of Epidermolysis Bullosa Acquisita: Multicentre Comparison of Diffe..., Acta Derm Venereol
2020

Emerging drugs for the treatment of epidermolysis bullosa., Expert Opin Emerg Drugs
2019

EBGene trial: patient preselection outcomes for the European GENEGRAFT ex viv..., Br J Dermatol
2019

A TP63 Mutation Causes Prominent Alopecia with Mild Ectodermal Dysplasia., J Invest Dermatol
2019

Safety and early efficacy outcomes for lentiviral fibroblast gene therapy in ..., JCI Insight
2018

Epidermolysis bullosa simplex-generalized severe type due to keratin 5 p.Glu4..., Pediatr Dermatol
2018

Correction to: Antisense-Mediated Splice Modulation to Reframe Transcripts., Methods Mol Biol
2018

Mutations in PERP Cause Dominant and Recessive Keratoderma., J Invest Dermatol
2018

Antisense-Mediated Splice Modulation to Reframe Transcripts., Methods Mol Biol
2018

APOBEC mutation drives early-onset squamous cell carcinomas in recessive dyst..., Sci Transl Med
2018

Intradermal Injection of Bone Marrow Mesenchymal Stromal Cells Corrects Reces..., J Invest Dermatol
2018

Ex Vivo COL7A1 Correction for Recessive Dystrophic Epidermolysis Bullosa Usin..., Mol Ther Nucleic Acids
2018

A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT..., Sci Immunol
2018

Diacerein orphan drug development for epidermolysis bullosa simplex: A phase ..., J Am Acad Dermatol
2017

The Molecular Revolution in Cutaneous Biology: Emerging Landscape in Genomic ..., J Invest Dermatol
2016

Selective Substrates and Inhibitors for Kallikrein-Related Peptidase 7 (KLK7)..., J Invest Dermatol
2016

Targeted Exon Skipping Restores Type VII Collagen Expression and Anchoring Fi..., J Invest Dermatol
2016

Gene-Corrected Fibroblast Therapy for Recessive Dystrophic Epidermolysis Bull..., J Invest Dermatol
2016

Comparison of 3 type VII collagen (C7) assays for serologic diagnosis of epid..., J Am Acad Dermatol
2016

Marked intrafamilial phenotypic heterogeneity in dystrophic epidermolysis bul..., Br J Dermatol
2015

KLK5 Inactivation Reverses Cutaneous Hallmarks of Netherton Syndrome., PLoS Genet
2014

HEK293-based production platform for γ-retroviral (self-inactivating) vectors..., Hum Gene Ther Clin Dev
2014

Transgenic kallikrein 5 mice reproduce major cutaneous and systemic hallmarks..., J Exp Med
2012

Antisense-mediated exon skipping to reframe transcripts., Methods Mol Biol
2012

siRNA-mediated allele-specific inhibition of mutant type VII collagen in domi..., J Invest Dermatol
2011

A new case of keratin 14 functional knockout causes severe recessive EBS and ..., J Invest Dermatol
2010

Induced pluripotent stem cells from individuals with recessive dystrophic epi..., J Invest Dermatol
2010

SIN retroviral vectors expressing COL7A1 under human promoters for ex vivo ge..., Mol Ther
2010

Gene therapy for recessive dystrophic epidermolysis bullosa., Dermatol Clin
2010

Immune reactivity to type VII collagen: implications for gene therapy of rece..., Gene Ther
2008

Keratitis-ichthyosis-deafness syndrome caused by GJB2 maternal mosaicism., J Invest Dermatol
2007

TLR3 deficiency in patients with herpes simplex encephalitis., Science
2006

DNA-based prenatal diagnosis of harlequin ichthyosis and characterization of ..., J Invest Dermatol
2006

Generalized epidermolytic hyperkeratosis in two unrelated children from paren..., J Invest Dermatol
2006

Recessive dystrophic epidermolysis bullosa caused by COL7A1 hemizygosity and ..., Hum Mutat
2006

Three severe cases of EBS Dowling-Meara caused by missense and frameshift mut..., J Invest Dermatol

Présentation

À propos

Publications scientifiques

ADAR1 loss-of-function variants altering RNA editing define a new interferon-..., Rockefeller University Press

Novel variants impairing Sp1 transcription factor binding in the COL7A1 promo..., Eur J Hum Genet

Splice modulation strategy applied to deep intronic variants in causing rece..., Proc Natl Acad Sci U S A

Citrullinated Histone H3, a Marker for Neutrophil Extracellular Traps, Is Ass..., Cancers (Basel)

Highly Efficient Ex Vivo Correction of COL7A1 through Ribonucleoprotein-Based..., Elsevier BV

Individuals with JAK1 variants are affected by syndromic features encompassin..., J Exp Med

Pachyonychia Congenita: A Research Agenda Leading to New Therapeutic Approaches., J Invest Dermatol

Generation and characterization of induced pluripotent stem cell lines from t..., Elsevier BV

Drug Repurposing Reveals mTOR Inhibition as a Promising Strategy for Epidermo..., J Invest Dermatol

Dystrophic epidermolysis bullosa pruriginosa: a new case series of a rare phe..., J Eur Acad Dermatol Venereol

Netherton syndrome subtypes share IL-17/IL-36 signature with distinct IFN-α a..., J Allergy Clin Immunol

Humans with inherited T cell CD28 deficiency are susceptible to skin papillom..., Cell

Diagnosis of Epidermolysis Bullosa Acquisita: Multicentre Comparison of Diffe..., Acta Derm Venereol

Emerging drugs for the treatment of epidermolysis bullosa., Expert Opin Emerg Drugs

EBGene trial: patient preselection outcomes for the European GENEGRAFT ex viv..., Br J Dermatol

A TP63 Mutation Causes Prominent Alopecia with Mild Ectodermal Dysplasia., J Invest Dermatol

Safety and early efficacy outcomes for lentiviral fibroblast gene therapy in ..., JCI Insight

Epidermolysis bullosa simplex-generalized severe type due to keratin 5 p.Glu4..., Pediatr Dermatol

Correction to: Antisense-Mediated Splice Modulation to Reframe Transcripts., Methods Mol Biol

Mutations in PERP Cause Dominant and Recessive Keratoderma., J Invest Dermatol

Antisense-Mediated Splice Modulation to Reframe Transcripts., Methods Mol Biol

APOBEC mutation drives early-onset squamous cell carcinomas in recessive dyst..., Sci Transl Med

Intradermal Injection of Bone Marrow Mesenchymal Stromal Cells Corrects Reces..., J Invest Dermatol

Ex Vivo COL7A1 Correction for Recessive Dystrophic Epidermolysis Bullosa Usin..., Mol Ther Nucleic Acids

A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT..., Sci Immunol

Diacerein orphan drug development for epidermolysis bullosa simplex: A phase ..., J Am Acad Dermatol

The Molecular Revolution in Cutaneous Biology: Emerging Landscape in Genomic ..., J Invest Dermatol

Selective Substrates and Inhibitors for Kallikrein-Related Peptidase 7 (KLK7)..., J Invest Dermatol

Targeted Exon Skipping Restores Type VII Collagen Expression and Anchoring Fi..., J Invest Dermatol

Gene-Corrected Fibroblast Therapy for Recessive Dystrophic Epidermolysis Bull..., J Invest Dermatol

Comparison of 3 type VII collagen (C7) assays for serologic diagnosis of epid..., J Am Acad Dermatol

Marked intrafamilial phenotypic heterogeneity in dystrophic epidermolysis bul..., Br J Dermatol

KLK5 Inactivation Reverses Cutaneous Hallmarks of Netherton Syndrome., PLoS Genet

HEK293-based production platform for γ-retroviral (self-inactivating) vectors..., Hum Gene Ther Clin Dev

Transgenic kallikrein 5 mice reproduce major cutaneous and systemic hallmarks..., J Exp Med

Antisense-mediated exon skipping to reframe transcripts., Methods Mol Biol

siRNA-mediated allele-specific inhibition of mutant type VII collagen in domi..., J Invest Dermatol

A new case of keratin 14 functional knockout causes severe recessive EBS and ..., J Invest Dermatol

Induced pluripotent stem cells from individuals with recessive dystrophic epi..., J Invest Dermatol

SIN retroviral vectors expressing COL7A1 under human promoters for ex vivo ge..., Mol Ther

Gene therapy for recessive dystrophic epidermolysis bullosa., Dermatol Clin

Immune reactivity to type VII collagen: implications for gene therapy of rece..., Gene Ther

Keratitis-ichthyosis-deafness syndrome caused by GJB2 maternal mosaicism., J Invest Dermatol

TLR3 deficiency in patients with herpes simplex encephalitis., Science

DNA-based prenatal diagnosis of harlequin ichthyosis and characterization of ..., J Invest Dermatol

Generalized epidermolytic hyperkeratosis in two unrelated children from paren..., J Invest Dermatol

Recessive dystrophic epidermolysis bullosa caused by COL7A1 hemizygosity and ..., Hum Mutat

Three severe cases of EBS Dowling-Meara caused by missense and frameshift mut..., J Invest Dermatol