Alexandre BENMERAH | Institut Imagine

Présentation

Dr, DR2 INSERM

Alexandre BENMERAH

Laboratoire des Maladies Rénales Héréditaires

Contact :

01 42 75 43 44

alexandre.benmerah@institutimagine.org

À propos

Alexandre Benmerah has a Cell Biology background with previous works focused on endocytosis and on the role of vesicular trafficking in the biogenesis of the primary cilium. After having headed a team at Cochin Institute for 12 years, he joined Sophie Saunier's group in 2013 to develop projects aiming to better understand the function of newly identified genes in nephronophthisis (NPHP), a renal ciliopathy. Alexandre Benmerah contributed to the foundation of the french network on cilia and ciliopathies (Club CFC) and is regularly involved in the organization of French and European cilia meetings. He is also involved in teaching at the Paris Cité University where he is heading the Master 2 "Developmental and Cell Biology" and member of the board of the MECA department of the BioSPC PhD program.

Projet scientifique

After having worked on the characterization of ciliary functions of new NPHP genes, Alexandre Benmerah joined the efforts of the team to develop therapeutic approaches for NPH and participated in the characterization of the effects of prostaglandin receptor agonists on ciliogenesis at the cellular level. His ongoing projects are pursuing these approaches aiming to identify and characterize new therapeutic compounds for NPHP using cellular and zebrafish embryo models.

Financements

Publications scientifiques

Publications

2026

Developmental switch dichotomizes kidney response to NPHP3 inactivation and t..., openRxiv
2026

COBT: a gene-based rare variant burden test for case-only study designs using..., Genome Med
2025

Primary cilia as architects of the neocortex: Roles in brain development, fun..., Dev Cell
2025

Exome Sequencing in a Large Cohort with Ciliopathy-Related Kidney Disease., Clin J Am Soc Nephrol
2025

Structure-Activity Analysis Reveals Perturbed Cilia-Jun N-Terminal Kinase Sig..., Kidney Int Rep
2025

Prostaglandin Analogs and Eupatilin as Treatments for Nephronophthisis., Kidney Int Rep
2024

The ANKS3/BICC1 protein complex is a master post-transcriptional regulator of..., openRxiv
2023

Fluid shear stress triggers cholesterol biosynthesis and uptake in inner medu..., Front Mol Biosci
2023

Meta-analysis of single-cell and single-nucleus transcriptomics reveals kidne..., Sci Data
2023

Repurposing small molecules for nephronophthisis and related renal ciliopathies., Kidney Int
2023

The genetic landscape and clinical spectrum of nephronophthisis and related c..., Kidney Int
2022

Biallelic KIF24 Variants Are Responsible for a Spectrum of Skeletal Disorders..., J Bone Miner Res
2022

Agonists of prostaglandin E receptors as potential first in class treatment f..., Proc Natl Acad Sci U S A
2021

Renal Ciliopathies: Sorting Out Therapeutic Approaches for Nephronophthisis., Front Cell Dev Biol
2021

Disruption of pathways regulated by Integrator complex in Galloway-Mowat synd..., Sci Rep
2020

Novel nephronophthisis-associated variants reveal functional importance of MA..., Kidney Int
2020

KIF14 controls ciliogenesis via regulation of Aurora A and is important for H..., J Cell Biol
2019

Cilia in hereditary cerebral anomalies., Biol Cell
2019

Human IFT52 mutations uncover a novel role for the protein in microtubule dyn..., Hum Mol Genet
2019

Ciliary kinesins beyond IFT: Cilium length, disassembly, cargo transport and ..., Biol Cell
2019

TBC1D8B Loss-of-Function Mutations Lead to X-Linked Nephrotic Syndrome via De..., Am J Hum Genet
2018

Loss-of-function mutations in KIF14 cause severe microcephaly and kidney deve..., Hum Mol Genet
2017

Functional characterization of tektin-1 in motile cilia and evidence for TEKT..., Hum Mol Genet
2017

Mutations in MAPKBP1 Cause Juvenile or Late-Onset Cilia-Independent Nephronop..., Am J Hum Genet
2017

Mutations in MAPKBP1 Cause Juvenile or Late-Onset Cilia-Independent Nephronop..., Am J Hum Genet
2016

Novel NEK8 Mutations Cause Severe Syndromic Renal Cystic Dysplasia through YA..., PLoS Genet
2015

Mutations in TRAF3IP1/IFT54 reveal a new role for IFT proteins in microtubule..., Nat Commun
2015

The more we know, the more we have to discover: an exciting future for unders..., Cilia
2015

Lysosomal Targeting of Cystinosin Requires AP-3., Traffic

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Présentation

À propos

Projet scientifique

Financements

Publications scientifiques

Developmental switch dichotomizes kidney response to NPHP3 inactivation and t..., openRxiv

COBT: a gene-based rare variant burden test for case-only study designs using..., Genome Med

Primary cilia as architects of the neocortex: Roles in brain development, fun..., Dev Cell

Exome Sequencing in a Large Cohort with Ciliopathy-Related Kidney Disease., Clin J Am Soc Nephrol

Structure-Activity Analysis Reveals Perturbed Cilia-Jun N-Terminal Kinase Sig..., Kidney Int Rep

Prostaglandin Analogs and Eupatilin as Treatments for Nephronophthisis., Kidney Int Rep

The ANKS3/BICC1 protein complex is a master post-transcriptional regulator of..., openRxiv

Fluid shear stress triggers cholesterol biosynthesis and uptake in inner medu..., Front Mol Biosci

Meta-analysis of single-cell and single-nucleus transcriptomics reveals kidne..., Sci Data

Repurposing small molecules for nephronophthisis and related renal ciliopathies., Kidney Int

The genetic landscape and clinical spectrum of nephronophthisis and related c..., Kidney Int

Biallelic KIF24 Variants Are Responsible for a Spectrum of Skeletal Disorders..., J Bone Miner Res

Agonists of prostaglandin E receptors as potential first in class treatment f..., Proc Natl Acad Sci U S A

Renal Ciliopathies: Sorting Out Therapeutic Approaches for Nephronophthisis., Front Cell Dev Biol

Disruption of pathways regulated by Integrator complex in Galloway-Mowat synd..., Sci Rep

Novel nephronophthisis-associated variants reveal functional importance of MA..., Kidney Int

KIF14 controls ciliogenesis via regulation of Aurora A and is important for H..., J Cell Biol

Cilia in hereditary cerebral anomalies., Biol Cell

Human IFT52 mutations uncover a novel role for the protein in microtubule dyn..., Hum Mol Genet

Ciliary kinesins beyond IFT: Cilium length, disassembly, cargo transport and ..., Biol Cell

TBC1D8B Loss-of-Function Mutations Lead to X-Linked Nephrotic Syndrome via De..., Am J Hum Genet

Loss-of-function mutations in KIF14 cause severe microcephaly and kidney deve..., Hum Mol Genet

Functional characterization of tektin-1 in motile cilia and evidence for TEKT..., Hum Mol Genet

Mutations in MAPKBP1 Cause Juvenile or Late-Onset Cilia-Independent Nephronop..., Am J Hum Genet

Mutations in MAPKBP1 Cause Juvenile or Late-Onset Cilia-Independent Nephronop..., Am J Hum Genet

Novel NEK8 Mutations Cause Severe Syndromic Renal Cystic Dysplasia through YA..., PLoS Genet

Mutations in TRAF3IP1/IFT54 reveal a new role for IFT proteins in microtubule..., Nat Commun

The more we know, the more we have to discover: an exciting future for unders..., Cilia

Lysosomal Targeting of Cystinosin Requires AP-3., Traffic