Présentation

Contact
Sven Kracker est directeur de recherche CNRS au laboratoire de lymphohématopoïèse humaine de l'institut Imagine.
Il a obtenu son doctorat à l'Université Humboldt de Berlin, en Allemagne et a poursuivi ses recherches à la Harvard Medical School dans le laboratoire de Klaus Rajewsky puis à l'hôpital Necker-Enfants Malades sous la supervision d'Anne Durandy.
Dans ses projets, il étudie la base moléculaire des déficiences en anticorps primaires dues à l'analyse phénotypique, fonctionnelle et génétique. Le but final de ses recherches est d'identifier de nouvelles cibles thérapeutiques pour les traitements. Il a participé à la description de plusieurs causes de déficiences en anticorps primaires parmi lesquelles la signalisation PI3Kδ activée causée par une mutation dans PIK3CD et PIK3R1.
Son travail est soutenu par des fondations nationales françaises et des fondations caritatives.
Ressources & publications
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Journal (source)Blood
Pediatric Evans syndrome is associated with a high frequency of potentially d...
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Journal (source)Nat. Genet.
Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculit...
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Journal (source)Haematologica
Evolution of disease activity and biomarkers on and off rapamycin in 28 patie...
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Journal (source)J. Clin. Immunol.
The Autoimmune Lymphoproliferative Syndrome with Defective FAS or FAS-Ligand ...
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Journal (source)Nature communications
Type I interferon-mediated autoinflammation due to DNase II deficiency.
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Journal (source)The journal of experimental medicine 2017
Detection of interferon alpha protein reveals differential levels and cellula...
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Journal (source)Blood Adv
Efficacy of ruxolitinib in subcutaneous panniculitis-like T-cell lymphoma and...
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Journal (source)J. Exp. Med.
Concomitant PIK3CD and TNFRSF9 deficiencies cause chronic active Epstein-Barr...
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Journal (source)The journal of experimental medicine 2020
Mutations in COPA lead to abnormal trafficking of STING to the Golgi and inte...
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Journal (source)Nat Commun
Early-onset autoimmunity associated with SOCS1 haploinsufficiency.
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Journal (source)J Clin Immunol
Differential Expression of Interferon-Alpha Protein Provides Clues to Tissue ...
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Journal (source)J Allergy Clin Immunol
Improving the diagnostic efficiency of primary immunodeficiencies with target...
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Journal (source)Front Immunol
Disease Evolution and Response to Rapamycin in Activated Phosphoinositide 3-K...
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Journal (source)Front Pediatr
Hematopoietic Stem Cell Transplant for the Treatment of X-MAID.
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Journal (source)Front Immunol
Disease Evolution and Response to Rapamycin in Activated Phosphoinositide 3-K...
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Journal (source)J Allergy Clin Immunol
Improving the diagnostic efficiency of primary immunodeficiencies with target...
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Journal (source)Am J Transplant
Donor-targeted serotherapy as a rescue therapy for steroid-resistant acute GV...
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Journal (source)Nat Immunol
Single-cell analysis of FOXP3 deficiencies in humans and mice unmasks intrins...
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Journal (source)Proc Natl Acad Sci U S A
Alternative pathways for the development of lymphoid structures in humans.
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Journal (source)Nat Med
Long-term outcomes of lentiviral gene therapy for the β-hemoglobinopathies: t...
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Journal (source)J Allergy Clin Immunol
Epithelial barrier dysfunction in desmoglein-1 deficiency.
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Journal (source)J Exp Med
Mutations in COPA lead to abnormal trafficking of STING to the Golgi and inte...
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Journal (source)J Exp Med
Mutations in COPA lead to abnormal trafficking of STING to the Golgi and inte...