Sven Kracker is a Research Director at CNRS whose work focuses on elucidating the molecular mechanisms underlying primary antibody deficiencies. His research combines phenotypic, functional, and genetic approaches to uncover disease causing pathways and identify novel therapeutic targets. He has contributed to defining several genetic etiologies, including gain- and loss-of-function mutations in PIK3CD and PIK3R1 that lead to hyperactive PI3Kδ signaling. More recently, his team has investigated the role of IRF4, a key transcription factor in B-cell differentiation, in immune dysregulation and immunodeficiency. His projects are supported by French national research programs and major charitable foundations.