Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children.

Bastard P, Gervais A, Taniguchi M, Saare L, Särekannu K, Le Voyer T, Philippot Q, Rosain J, Bizien L, Asano T, Garcia-Prat M, Parra-Martínez A, Migaud M, Tsumura M, Conti F, Belot A, Rivière JG, Morio T, Tanaka J, Javouhey E, Haerynck F, Duvlis S, Ozcelik T, Keles S, Tandjaoui-Lambiotte Y, Escoda S, Husain M, Pan-Hammarström Q, Hammarström L, Ahlijah G, Abi Haidar A, Soudee C, Arseguel V, Abolhassani H, Sahanic S, Tancevski I, Nukui Y, Hayakawa S, Chrousos GP, Michos A, Tatsi EB, Filippatos F, Rodriguez-Palmero A, Troya J, Tipu I, Meyts I, Roussel L, Ostrowski SR, Schidlowski L, Prando C, Condino-Neto A, Cheikh N, Bousfiha AA, El Bakkouri J, Peterson P, Pujol A, Lévy R, Quartier P, Vinh DC, Boisson B, Béziat V, Zhang SY, Borghesi A, Pession A, Andreakos E, Marr N, Mentis AA, Mogensen TH, Rodríguez-Gallego C, Soler-Palacin P, Colobran R, Tillmann V, Neven B, Trouillet-Assant S, Brodin P, Abel L, Jouanguy E, Zhang Q, Martinón-Torres F, Salas A, Gómez-Carballa A, Gonzalez-Granado LI, Kisand K, Okada S, Puel A, Cobat A, Casanova JL, Aguilera-Albesa S, AlKhater SA, Alkan G, Castagnoli R, Cyrus C, Elmas Bozdemir S, Emiroglu M, Gulhan B, Erdeniz EH, Hatipoglu N, Bayhan GI, Jabandziev P, Kanik Yuksek S, Karbuz A, Tüter Öz ŞK, Marseglia GL, Metin Akcan O, Kılıç AO, Ozkaya Parlakay A, Papadaki M, Slaba K, Sevketoglu E, Valencia-Ramos J, Yahşi A, Aguilera Guirao A, Álvarez Escudero J, Antela López A, Barbeito Castiñeiras G, Bello Paderne X, Ben García M, Carral García MV, Cebey López M, Coira Nieto A, Conde Pájaro M, Costa Alcalde JJ, Currás Tuala MJ, Dacosta Urbieta AI, Díaz Esteban B, Domínguez Santalla MJ, Fernández Pérez C, Fernández Villaverde J, Galbán Rodríguez C, García Allut JL, García Vicente L, Giráldez Vázquez E, Gómez Carballa A, Gómez Rial J, González Barcala FJ, Guerra Liñares B, Leboráns Iglesias P, Lence Massa B, Lendoiro Fuentes M, López Franco M, López Lago A, Martinón-Torres F, Salas A, Navarro De la Cruz D, Núñez Masid E, Ortolá Devesa JB, Pardo Seco J, Pazo Núñez M, Pérez Del Molino Bernal M, Pérez Freixo H, Piñeiro Rodríguez L, Pischedda S, Portela Romero M, Pose Reino A, Prada Hervella GM, Queiro Verdes T, Redondo Collazo L, Regueiro Casuso P, Rey García S, Rey Vázquez S, Riveiro Blanco V, Rivero Calle I, Rivero Velasco C, Rodríguez Núñez N, Rodríguez-Tenreiro Sánchez C, Saborido Paz E, Sadiki Orayyou JM, Saito Villanueva C, Serén Fernández S, Souto Sanmartín P, Taboada Muñiz M, Trastoy Pena R, Treviño Castellano M, Valdés Cuadrado L, Varela García P, Vilas Iglesias MS, Viz Lasheras S, Ferreiro-Iglesias R, Bastón-Rey I, Calviño-Suárez C, Abel L, Aiuti A, Al-Muhsen S, Al-Mulla F, Amara A, Anderson MS, Andreakos E, Arias AA, Arkin LM, Baris Feldman H, Bastard P, Belot A, Biggs CM, Bogunovic D, Bolze A, Bondarenko A, Bousfiha AA, Brodin P, Bryceson Y, Butte MJ, Casanova JL, Casari G, Christodoulou J, Cobat A, Colobran R, Condino-Neto A, Constantinescu SN, Cooper MA, Dalgard CL, Desai M, Drolet BA, Duval X, El Baghdadi J, Eloy P, Espinosa-Padilla S, Fellay J, Flores C, Franco JL, Froidure A, Gorochov G, Gregersen PK, Grimbacher B, Haerynck F, Hagin D, Halwani R, Hammarström L, Heath JR, Hsieh EWY, Husebye E, Imai K, Itan Y, Jarvis ED, Jouanguy E, Kaja E, Karamitros T, Kisand K, Ku CL, Lau YL, Ling Y, Lucas CL, Mansouri D, Maródi L, Mentré F, Meyts I, Milner JD, Mironska K, Mogensen TH, Morio T, Ng LFP, Notarangelo LD, Novelli A, Novelli G, O'Farrelly C, Okada S, Okamoto K, Ozcelik T, Pan-Hammarström Q, Pape JW, Perez de Diego R, Perez-Tur J, Perlin DS, Pesole G, Planas AM, Prando C, Pujol A, Puel A, Quintana-Murci L, Ramaswamy S, Renia L, Resnick I, Rodríguez-Gallego C, Sancho-Shimizu V, Sediva A, Seppänen MRJ, Shahrooei M, Shcherbina A, Slaby O, Snow AL, Soler-Palacín P, Soumelis V, Spaan AN, Su HC, Tancevski I, Tangye SG, Abou Tayoun A, Temel ŞG, Thorball C, Tiberghien P, Trouillet-Assant S, Turvey SE, Furkan Uddin KM, Uddin MJ, van de Beek D, Vinh DC, von Bernuth H, Wauters J, Zatz M, Zawadzki P, Zhang Q, Zhang SY.

Source :

J Exp Med

2024 Feb 5

Pmid / DOI:

PMID: 38175961

Abstract

We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only in three, IFN-α2 plus IFN-ω in five, and IFN-α2, IFN-ω plus IFN-β in two; IFN-ω only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-α2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-ω in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-α2 only (OR [95% CI] = 67.6 [5.7-9,196.6]) than for auto-Abs neutralizing IFN-ω only (OR [95% CI] = 2.6 [1.2-5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6-35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1-9.6]) of IFN-ω and/or IFN-α2.

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