Meta-analysis of single-cell and single-nucleus transcriptomics reveals kidney cell type consensus signatures.
Quatredeniers M, Serafin AS, Benmerah A, Rausell A, Saunier S, Viau A.
    Source :
    
                  
            Sci Data
      
              
  
    
                  
            2023 Jun 6
      
              
  
      Pmid / DOI:
      
                    
            37280226 
      
                
    
Abstract
While the amount of studies involving single-cell or single-nucleus RNA-sequencing technologies grows exponentially within the biomedical research area, the kidney field requires reference transcriptomic signatures to allocate each cluster its matching cell type. The present meta-analysis of 39 previously published datasets, from 7 independent studies, involving healthy human adult kidney samples, offers a set of 24 distinct consensus kidney cell type signatures. The use of these signatures may help to assure the reliability of cell type identification in future studies involving single-cell and single-nucleus transcriptomics while improving the reproducibility in cell type allocation.
      
                              
                            
            