Meta-analysis of single-cell and single-nucleus transcriptomics reveals kidney cell type consensus signatures.

Quatredeniers M, Serafin AS, Benmerah A, Rausell A, Saunier S, Viau A.

Source :

Sci Data

2023 Jun 6

Pmid / DOI:

37280226

Abstract

While the amount of studies involving single-cell or single-nucleus RNA-sequencing technologies grows exponentially within the biomedical research area, the kidney field requires reference transcriptomic signatures to allocate each cluster its matching cell type. The present meta-analysis of 39 previously published datasets, from 7 independent studies, involving healthy human adult kidney samples, offers a set of 24 distinct consensus kidney cell type signatures. The use of these signatures may help to assure the reliability of cell type identification in future studies involving single-cell and single-nucleus transcriptomics while improving the reproducibility in cell type allocation.

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