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Tristan graduated from University Pierre & Marie Curie (Sorbonne University, France) where he obtained a Master degree in Biochemistry, in 2008. During his Master internship, he worked on microRNA interference in medulloblastoma in the team of Dr. Graeme Hodgson at University of California, San Francisco (USA).

He was recruited as junior technicia in the laboratory of Dr. Pierre-Louis Tharaux at PaRis Cardiovascular research Center (PaRCC, France), and then in the team of Dr. Marco Pontoglio at Cochin Institute (France) where he worked on kidney diseases.

In 2011, he worked in the laboratory of Dr. Pierre Charneau at Pasteur Institute (France), under the supervision of Dr. Anne-Sophie Beignon. He was in charge of a project focused on novel lentiviral vaccines to cure malaria, by which he acquired an expertise in immunology and virology. Then, he joined the laboratory of Pr. Claude Leclerc at Pasteur Institute, where he led a project focused on lentiviral vaccination.

In 2014, Tristan joined the laboratory of Dr. Annarita Miccio, where he is currently working on the development of innovative CRISPR/Cas9 based gene therapy strategies to treat β-hemoglobinopathies and on the epigenetic regulation during erythropoiesis.