Discovery and characterization of a novel humanized anti-IL-15 antibody and its relevance for the treatment of refractory celiac disease and eosinophilic esophagitis.
Vicari A,Schoepfer A,Meresse B,Goffin L,Léger O,Josserand S,Guégan N,Yousefi S,Straumann A,Cerf-Bensussan N,Simon H,Chvatchko Y
Source :
2017 Jun 5
Pmid / DOI:
28581883
Abstract
Interleukin-15 (IL-15) is a critical regulator of immune responses, especially at mucosal interfaces within the gastro-intestinal tract. Here, we describe the discovery and characterization of a humanized antibody to IL-15. Data from its epitope and mode of action, cell biology and primate pharmacology, as well as translational studies in human samples and in vivo proof-of-concept experiments in mouse models demonstrate the therapeutic potential of this new antibody targeting IL-15 for refractory celiac disease and eosinophilic esophagitis.KEYWORDSAntibody, IL-15, celiac disease, cis, eosinophilic esophagitis, humanized, interleukin-15, trans