Males with sickle cell disease have higher risks of cerebrovascular disease, increased inflammation, and a reduced response to hydroxyurea.
Di Mauro M,El Hoss S,Nardo-Marino A,Stuart-Smith S,Strouboulis J,Gibson J,Rees D,Brewin J
Source :
2023 Aoû 30
Pmid / DOI:
37646569
Abstract
Biological sex is important. Male sex is associated with worse outcomes in most measures, including cerebrovascular disease, hospital admissions, and blood transfusions, but not survival. Females also appear to have a better response to hydroxyurea therapy, reduced markers of inflammation, and better liver function.© 2023 Wiley Periodicals LLC.