Neutropenia in Patients with Common Variable Immunodeficiency: a Rare Event Associated with Severe Outcome.
Guffroy A,Mourot-Cottet R,Gérard L,Gies V,Lagresle C,Pouliet A,Nitschké P,Hanein S,Bienvenu B,Chanet V,Donadieu J,Gardembas M,Karmochkine M,Nove-Josserand R,Martin T,Poindron V,Soulas-Sprauel P,Rieux-Laucat F,Fieschi C,Oksenhendler E,André-Schmutz I,Korganow A
Source :
J Clin Immunol
2017 Aoû 26
Pmid / DOI:
28842786
Abstract
BACKGROUNDCommon variable immunodeficiency (CVID) is characterized by infections and hypogammaglobulinemia. Neutropenia is rare during CVID.METHODSThe French DEFI study enrolled patients with primary hypogammaglobulinemia. Patients with CVID and neutropenia were retrospectively analyzed.RESULTSAmong 473 patients with CVID, 16 patients displayed neutropenia (lowest count [0-1400]*10/L). Sex ratio (M/F) was 10/6. Five patients died during the follow-up (11 years) with an increased percentage of deaths compared to the whole DEFI group (31.3 vs 3.4%, P