A novel transient glutamatergic population migrating from the pallial-subpallial boundary contributes to neocortical development.
Teissier A,Griveau A,Vigier L,Piolot T,Borello U,Pierani A
Source :
J. Neurosci.
2010 Aoû 6
Pmid / DOI:
20685999
Abstract
The generation of a precise number of neural cells and the determination of their laminar fate are tightly controlled processes during development of the cerebral cortex. Using genetic tracing in mice, we have identified a population of glutamatergic neurons generated by Dbx1-expressing progenitors at the pallial-subpallial boundary predominantly at embryonic day 12.5 (E12.5) and subsequent to Cajal-Retzius cells. We show that these neurons migrate tangentially to populate the cortical plate (CP) at all rostrocaudal and mediolateral levels by E14.5. At birth, they homogeneously populate cortical areas and represent