Présentation
Contact
Chantal Lagresle-Peyrou est cheffe de projet au Centre d'Investigation Clinique de Biothérapie dirigé par Marina Cavazzana, lié au laboratoire de Lymphohématopoïèse Humaine de l'institut Imagine, Paris. Elle travaille depuis 15 ans sur le développement de stratégies de thérapie génique pour plusieurs formes de SCID. Elle possède une expertise sur les modèles de xénotransplantation tels que les souris NSG et elle est responsable de toutes les expériences de xénotransplantation réalisées pour les protocoles de thérapie génique développés en laboratoire. Elle travaille également sur la caractérisation moléculaire des immunodéficiences primaires. Chantal Lagresle-Peyrou a fait partie de plusieurs consortiums européens pour le développement préclinique de la thérapie génique des troubles immunitaires héréditaires.
Ressources & publications
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Journal (source)Mol Ther Methods Clin DevBiosafety Studies of a Clinically Applicable Lentiviral Vector for the Gene T...
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2024Journal (source)Cancer ResComprehensive Genetic Profiling Reveals Frequent Alterations of Driver Genes ...
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2021Journal (source)Cell Mol ImmunolA DL-4- and TNFα-based culture system to generate high numbers of nonmodified...
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2017Journal (source)Stem Cells DevGene Therapy with Hematopoietic Stem Cells: The Diseased Bone Marrow's Point ...
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2014Journal (source)J Allergy Clin ImmunolRecombination-activating gene 1 (Rag1)-deficient mice with severe combined im...
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2014Journal (source)J Allergy Clin ImmunolSuccessful RAG1-SCID gene therapy depends on the level of RAG1 expression.
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2014Journal (source)J Allergy Clin ImmunolThe BLNK adaptor protein has a nonredundant role in human B-cell differentiat...
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2015Journal (source)J Allergy Clin ImmunolAn in vivo genetic reversion highlights the crucial role of Myb-Like, SWIRM, ...
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2017Journal (source)BloodReticular dysgenesis: international survey on clinical presentation, transpla...
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2021Journal (source)BloodA combination of cyclophosphamide and interleukin-2 allows CD4+ T cells conve...
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2021Journal (source)Blood AdvAdenylate kinase 2 expression and addiction in T-ALL.
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2021Journal (source)J Allergy Clin ImmunolImproving the diagnostic efficiency of primary immunodeficiencies with target...
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2019Journal (source)Blood AdvBaboon envelope LVs efficiently transduced human adult, fetal, and progenitor...
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2019Journal (source)Front PediatrHematopoietic Stem Cell Transplant for the Treatment of X-MAID.
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Journal (source)Mol Ther Methods Clin DevA Nontoxic Transduction Enhancer Enables Highly Efficient Lentiviral Transduc...
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2020Journal (source)Hum Mol GenetNHP2 deficiency impairs rRNA biogenesis and causes pulmonary fibrosis and Høy...
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Journal (source)Mol Ther Methods Clin DevSuccessful Preclinical Development of Gene Therapy for Recombinase-Activating...
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2021Journal (source)J Allergy Clin ImmunolImproving the diagnostic efficiency of primary immunodeficiencies with target...
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2020Journal (source)HaematologicaA gain-of-function RAC2 mutation is associated with bone-marrow hypoplasia an...
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2013Journal (source)Stem CellsHuman T-lymphoid progenitors generated in a feeder-cell-free Delta-like-4 cul...
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2016Journal (source)Cell Death DisAK2 deficiency compromises the mitochondrial energy metabolism required for d...
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2019Journal (source)Blood AdvGene transfer into hematopoietic stem cells reduces HLH manifestations in a m...
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Journal (source)J. Allergy Clin. Immunol.X-linked primary immunodeficiency associated with hemizygous mutations in the...
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2018Journal (source)BloodGene-corrected human Munc13-4-deficient CD8+ T cells can efficiently restrict...
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2017Journal (source)Stem Cells Dev.Gene Therapy with Hematopoietic Stem Cells: The Diseased Bone Marrow's Point ...
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2016Journal (source)Hum. Gene Ther.Gene Therapy for X-Linked Severe Combined Immunodeficiency: Where Do We Stand?
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Journal (source)J. Allergy Clin. Immunol.Generation of adult human T-cell progenitors for immunotherapeutic applications.
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2019Journal (source)HaematologicaPlerixafor enables safe, rapid, efficient mobilization of hematopoietic stem ...