Often, genetic diseases are complex diseases that call for both the development of new diagnostic tools and the discovery of new treatment options.
Imagine teams conceive and conduct clinical research projects, mobilizing patients, doctors, researchers, clinical research professionals, and sometimes public or private partners, to validate whether scientific hypotheses in humans are accurate or not, with all the necessary precautions and with respect for the current regulations.
These developments help to better understand diseases, test new diagnostic and therapeutic approaches, and are a prerequisite to future marketing of new solutions in aid of patients.
Today, Imagine is involved in more than 500 clinical studies, including 30 clinical proof of concept studies.
This work mobilizes two Clinical Investigation Centers that make up the scope of Imagine, the mother-child CIC, combined with the Paris Center Descartes Clinical Research Unit, directed by Prof. Jean-Marc Tréluyer, and the CIC specialized in Biotherapy (CIC-BT), directed by Prof. Marina Cavazzana. These clinical research structures provide substantial resources and expertise needed to develop projects.
Imagine Institute provides additional resources with the aim of increasing the number of studies, particularly in the field of innovative therapies (gene and cell therapies), accelerating their implementation, and increasing the number of patients enrolled in clinical studies.
Human resources provided by Imagine to increase clinical research capacities
Since 2012, Imagine has dedicated substantial means to strengthening the expertise and resources available on campus at Necker-Enfants malades and within AP-HP and Inserm. Clinical research teams directed by Salma Kotti serve the clinicians and researchers at Imagine Institute.
A sponsorship support team, made up of project managers are particularly involved in the investigation and implementation of AP-HP or Inserm sponsored studies. An investigation support team, made up of clinical research coordinators, clinical study technicians and mobile clinical research nurses operate by supporting medical teams in conducting studies.