CRISPR/Cas9: a patch on the DNA double helix?

The 2020 Nobel Prize in Chemistry rewarded the work of Emmanuelle Charpentier and Jennifer Doudna on the correction of the genome using the CRISPR/Cas9 technique they developed. Arnold Munnich, pediatrician, geneticist, and president of the Imagine Genetic Diseases Foundation, and Annarita Miccio, director of the chromatin and gene regulation during development laboratory at Imagine, report in the December 2020 issue of La Revue du Praticien on this tool, its use in the laboratory today, its limits and its contributions.