A new 3p25 locus is associated with liver fibrosis progression in human immunodeficiency virus/hepatitis C virus-coinfected patients.
Ulveling D,Le Clerc S,Cobat A,Labib T,Noirel J,Laville V,Coulonges C,Carpentier W,Nalpas B,Heim M,Poynard T,Cerny A,Pol S,Bochud P,Dabis F,Theodorou I,Lévy Y,Salmon D,Abel L,Dominguez S,Zagury J
Source :
Hepatology
2016 Jul 29
Pmid / DOI:
27339598
Abstract
UNLABELLEDThere is growing evidence that human genetic variants contribute to liver fibrosis in subjects with hepatitis C virus (HCV) monoinfection, but this aspect has been little investigated in patients coinfected with HCV and human immunodeficiency virus (HIV). We performed the first genome-wide association study of liver fibrosis progression in patients coinfected with HCV and HIV, using the well-characterized French National Agency for Research on AIDS and Viral Hepatitis CO13 HEPAVIH cohort. Liver fibrosis was assessed by elastography (FibroScan), providing a quantitative fibrosis score. After quality control, a genome-wide association study was conducted on 289 Caucasian patients, for a total of 8,426,597 genotyped (Illumina Omni2.5 BeadChip) or reliably imputed single-nucleotide polymorphisms. Single-nucleotide polymorphisms with P values