Sylvain Ernest

Research Scientist | Jeanne Amiel

Presentation

Sylvain Ernest

Contact

Send a message

Sylvain Ernest is interested in genetic deafness. He has studied Myo7a, a gene implicated in Usher syndrome, a syndrome associating early onset deafness and blindness at puberty. He uses the zebrafish as animal model for deciphering the role of genes, whose malfunction is responsible for deafness.

 

Since his arrival at Imagine Institute, he is working on rare forms of sensoryneural deafness, using a combination of genomic, molecular and cellular approaches, in the zebrafish, in order to elucidate the function of genes important for the audition in human.

 

ISH + Tg myo7aa
Expression of Myo7a in sensory hair cells (inner ear and neuromasts) of zebrafish. Left: in situ hybridization. Right: transgenic zebrafish expressing EGFP fluorescent protein under the control of a Myo7a regulatory element. © Sylvain Ernest

 

 

Myo7aa + actin in SHC
Expression of Myo7aa-mCherry fusion protein (red) in sensory hair cells of zebrafish inner ear. Labeling of actin rich hair bundles (green). © Sylvain Ernest

 

 

 

Some publications (see below) about the study of Myo7a gene:

 

  • Article describing the identification and the characterization of the first zebrafish model of human deafness

 

  • Study of the regulation of Myo7a gene expression in zebrafish

 

 

 

Abstract 04

Research: a scientific adventure

Our goal: to better understand genetic diseases to better treat them.