Résultat de recherche

Cytotoxic granule secretion by lymphocytes and its link to immune homeostasis.

Alain Fischer, Fernando Sepulveda , Geneviève de Saint Basile

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Polygenic mutations in the cytotoxicity pathway increase susceptibility to develop HLH immunopathology in mice.

Geneviève de Saint Basile, Fernando Sepulveda , Gaël Ménasché, Alain Fischer

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A novel immunoregulatory role for NK-cell cytotoxicity in protection from HLH-like immunopathology in mice.

Geneviève de Saint Basile, Fernando Sepulveda , Gaël Ménasché, Alain Fischer, Mathieu Kurowska

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Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome.

Geneviève de Saint Basile, Fernando Sepulveda , Bénédicte Neven, Alain Fischer, Frédéric Guérin

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GATA factor transcriptional activity: Insights from genome-wide binding profiles.

Annarita Miccio , Oriana Romano

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Extensive multilineage analysis in patients with mixed chimerism after allogeneic transplantation for sickle cell disease: insight into hematopoiesis and engraftment thresholds for gene therapy.

Marina Cavazzana

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Lentiviral and genome-editing strategies for the treatment of β-hemoglobinopathies.

Marina Cavazzana, Annarita Miccio

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Gene therapy of hemoglobinopathies: progress and future challenges.

Marina Cavazzana

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Gene therapy targeting haematopoietic stem cells for inherited diseases: progress and challenges.

Annarita Miccio , Emmanuelle SIX, Isabelle André, Marina Cavazzana

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Optimization of CRISPR/Cas9 Delivery to Human Hematopoietic Stem and Progenitor Cells for Therapeutic Genomic Rearrangements.

Annarita Miccio

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An Optimized Lentiviral Vector Efficiently Corrects the Human Sickle Cell Disease Phenotype.

Annarita Miccio

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