Résultat de recherche

Distinct severity of HLH in both human and murine mutants with complete loss of cytotoxic effector PRF1, RAB27A, and STX11.

Geneviève de Saint Basile, Fernando Sepulveda , Gaël Ménasché, Mathieu Kurowska, Alain Fischer

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Graded defects in cytotoxicity determine severity of hemophagocytic lymphohistiocytosis in humans and mice.

Geneviève de Saint Basile, Fernando Sepulveda

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LYST controls the biogenesis of the endosomal compartment required for secretory lysosome function.

Geneviève de Saint Basile, Fernando Sepulveda , Gaël Ménasché, Alain Fischer

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Cytotoxic granule secretion by lymphocytes and its link to immune homeostasis.

Alain Fischer, Fernando Sepulveda , Geneviève de Saint Basile

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Polygenic mutations in the cytotoxicity pathway increase susceptibility to develop HLH immunopathology in mice.

Geneviève de Saint Basile, Fernando Sepulveda , Gaël Ménasché, Alain Fischer

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A novel immunoregulatory role for NK-cell cytotoxicity in protection from HLH-like immunopathology in mice.

Geneviève de Saint Basile, Fernando Sepulveda , Gaël Ménasché, Alain Fischer, Mathieu Kurowska

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Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome.

Geneviève de Saint Basile, Fernando Sepulveda , Bénédicte Neven, Alain Fischer, Frédéric Guérin

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GATA factor transcriptional activity: Insights from genome-wide binding profiles.

Annarita Miccio , Oriana Romano

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Extensive multilineage analysis in patients with mixed chimerism after allogeneic transplantation for sickle cell disease: insight into hematopoiesis and engraftment thresholds for gene therapy.

Marina Cavazzana

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Lentiviral and genome-editing strategies for the treatment of β-hemoglobinopathies.

Marina Cavazzana, Annarita Miccio

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Gene therapy of hemoglobinopathies: progress and future challenges.

Marina Cavazzana

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