About
Understanding innate immune dysregulation in human autoinflammation
Our research is integrated within the broader theme of understanding the homeostasis of type I interferon (IFN-I) signalling and the pathogenic consequences of aberrant recognition of self-derived nucleic acids.
Within this framework, my group focus on how dysregulated innate immune sensing—particularly of mitochondrial nucleic acids—drives human autoinflammatory diseases such as neuroinflammation and lupus. We also investigate whether breaks in tolerance to mitochondrial nucleic acids contribute to inflammation and pathogenesis in mitochondrial disorders.
By leveraging insights from rare Mendelian diseases and patient cohorts, our work aims to uncover fundamental principles of immune regulation with direct relevance to both rare and common inflammatory conditions.
Scientific project
Research projects
Mitochondria and type I interferons: A better molecular understanding of the interferonogenic potential of mitochondria and a description of its physiological relevance to rare and common disease.
Innate immune pathway crosstalk: An exploration of the reciprocal influences between distinct branches of intracellular immunity underlying the complexity of autoinflammatory diseases to design bespoke combinations of therapeutic strategies.
Cellular basis of neuroinflammation: Use of iPSC derived models to identify the relevant sources and targets of type I interferon and neurotoxic mediators in interferon-mediated neuroinflammatory conditions.
Short CVSince 2022: Inserm permanent researcher, leader of the “Mitochondria and Interferon” group, Imagine Institute, Paris
205: Habilitation à Diriger des Recherches (HDR)
2018-2021: Postdoctoral researcher, Imagine Institute, Paris (Laboratory of Yanick Crow)
2012-2018: Postdoctoral researcher, Columbia University Medical Center, New York City (Laboratory of Sankar Ghosh)
2007-2011: PhD in Virology, Pasteur Institute, Paris (Laboratory of Olivier Schwartz)
Main fundingANR JCJC 2022-2025
ANR PRC 2023-2027, 2024-2028
FRM Neurodegenerative diseases 2024-2027
AFM Mitocall 2025-2027
2025Journal (source)Lancet Neurol