Alice Lepelley

Post-Doc | Yanick Crow



+33 1 42 75 44 43

Illustrating my strong interest in innate immunity and sensing, I described mechanisms of innate sensing of HIV-1 by specialized plasmacytoid dendritic cells during my PhD at Institut Pasteur in Paris under the supervision of Pr Olivier Schwartz (PhD in Virology from Université Pierre et Marie Curie in 2011). I then moved to Columbia University in New York City (Laboratory of Pr Sankar Ghosh, Microbiology and Immunology Department) to understand the role of mitochondrial homeostasis in macrophages and during neurodegeneration in collaboration with Pr Ottavio Arancio in the Center for Alzheimer’s Disease Research (2012-2018). Since 2018, I have joined the laboratory of Pr Yanick Crow to study the genetic causes of type I interferonopathies and understand the role of intracellular trafficking and organelles in innate immune signaling.

Activite de laboratoire

Research: a scientific adventure

Our goal: to better understand genetic diseases to better treat them.