Emmanuelle SIX | Institut Imagine

Presentation

Emmanuelle SIX

Chromatin and gene regulation during development

Contact :

01 42 75 44 06

emmanuelle.six@inserm.fr

About

Scientific Publications

Publications

2026

Somatic deficiency of the human E3 ubiquitin ligase CBL in leukocytes impairs..., Nat Immunol
2025

Severe inflammation and lineage skewing are associated with poor engraftment ..., Nat Commun
2024

Autoinflammation in patients with leukocytic CBL loss of heterozygosity is ca..., J Clin Invest
2024

FLT3L governs the development of partially overlapping hematopoietic lineages..., Cell
2023

The Antioxidant TEMPOL Protects Human Hematopoietic Stem Cells From Culture-M..., Stem Cells Transl Med
2023

Severe hematopoietic stem cell inflammation compromises chronic granulomatous..., Cell Rep Med
2022

Human kidney-derived hematopoietic stem cells can support long-term multiline..., Kidney Int
2022

Long-term outcomes of lentiviral gene therapy for the β-hemoglobinopathies: t..., Nat Med
2021

Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced d..., Nat Commun
2021

A DL-4- and TNFα-based culture system to generate high numbers of nonmodified..., Cell Mol Immunol
2021

Gene signature extraction and cell identity recognition at the single-cell le..., Nat Biotechnol
2021

Single-cell analysis of FOXP3 deficiencies in humans and mice unmasks intrins..., Nat Immunol
2021

Adenylate kinase 2 expression and addiction in T-ALL., Blood Adv
2021

A combination of cyclophosphamide and interleukin-2 allows CD4+ T cells conve..., Blood
2020

Clonal tracking in gene therapy patients reveals a diversity of human hematop..., Blood
2019

Extensive multilineage analysis in patients with mixed chimerism after alloge..., Haematologica
2019

Gene therapy targeting haematopoietic stem cells for inherited diseases: prog..., Nat Rev Drug Discov
2018

A Nontoxic Transduction Enhancer Enables Highly Efficient Lentiviral Transduc..., Mol Ther Methods Clin Dev
2017

Single-cell analysis reveals the continuum of human lympho-myeloid progenitor..., Nat Immunol
2016

Gene Therapy for X-Linked Severe Combined Immunodeficiency: Where Do We Stand?, Hum Gene Ther
2015

AK2 deficiency compromises the mitochondrial energy metabolism required for d..., Cell Death Dis
2015

Outcomes following gene therapy in patients with severe Wiskott-Aldrich syndr..., JAMA
2013

Genotoxic signature in cord blood cells of newborns exposed in utero to a Zid..., J Infect Dis
2012

Human T-lymphoid progenitors generated in a feeder-cell-free Delta-like-4 cul..., Stem Cells

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Presentation

About

Scientific Publications

Somatic deficiency of the human E3 ubiquitin ligase CBL in leukocytes impairs..., Nat Immunol

Severe inflammation and lineage skewing are associated with poor engraftment ..., Nat Commun

Autoinflammation in patients with leukocytic CBL loss of heterozygosity is ca..., J Clin Invest

FLT3L governs the development of partially overlapping hematopoietic lineages..., Cell

The Antioxidant TEMPOL Protects Human Hematopoietic Stem Cells From Culture-M..., Stem Cells Transl Med

Severe hematopoietic stem cell inflammation compromises chronic granulomatous..., Cell Rep Med

Human kidney-derived hematopoietic stem cells can support long-term multiline..., Kidney Int

Long-term outcomes of lentiviral gene therapy for the β-hemoglobinopathies: t..., Nat Med

Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced d..., Nat Commun

A DL-4- and TNFα-based culture system to generate high numbers of nonmodified..., Cell Mol Immunol

Gene signature extraction and cell identity recognition at the single-cell le..., Nat Biotechnol

Single-cell analysis of FOXP3 deficiencies in humans and mice unmasks intrins..., Nat Immunol

Adenylate kinase 2 expression and addiction in T-ALL., Blood Adv

A combination of cyclophosphamide and interleukin-2 allows CD4+ T cells conve..., Blood

Clonal tracking in gene therapy patients reveals a diversity of human hematop..., Blood

Extensive multilineage analysis in patients with mixed chimerism after alloge..., Haematologica

Gene therapy targeting haematopoietic stem cells for inherited diseases: prog..., Nat Rev Drug Discov

A Nontoxic Transduction Enhancer Enables Highly Efficient Lentiviral Transduc..., Mol Ther Methods Clin Dev

Single-cell analysis reveals the continuum of human lympho-myeloid progenitor..., Nat Immunol

Gene Therapy for X-Linked Severe Combined Immunodeficiency: Where Do We Stand?, Hum Gene Ther

AK2 deficiency compromises the mitochondrial energy metabolism required for d..., Cell Death Dis

Outcomes following gene therapy in patients with severe Wiskott-Aldrich syndr..., JAMA

Genotoxic signature in cord blood cells of newborns exposed in utero to a Zid..., J Infect Dis

Human T-lymphoid progenitors generated in a feeder-cell-free Delta-like-4 cul..., Stem Cells