Martin HORAK

Post-doctoral researcher | Agnès Rötig

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Martin HORAK

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Martin has started his scientific career at Masaryk University in Brno, Czech Republic, where he obtained his Ph.D. in Molecular and Cellular Biology and Genetics in 2019. His project was focused on the characterization of the role of Follistatin like 1 in mitochondria and its involvement in cardiovascular diseases. During his Ph.D. studies, he became interested in how mitochondrial dysfunction leads to impaired energy production and mitochondrial disease. In 2019, he was awarded a fellowship from the French Muscular Dystrophy Association (AFM-TELETHON), which enabled him to join the laboratory of Dr. Agnès RÖTIG for his postdoctoral research.

 

His current post-doctoral research conducted under the supervision of Dr. Metodi METODIEV is focused on the processing of nuclear-encoded proteins imported to mitochondria as well as the impact of its dysregulation on the mitochondrial functions. Since the vast majority of mitochondrial proteins are encoded by the nucleus, dysfunction of one or more peptidases responsible for their proper maturation can affect various mitochondrial functions including the impairment of the oxidative phosphorylation (OXPHOS) activity and, ultimately, cause mitochondrial disease. Better characterization of the mitochondrial post-translational processing in general as well as identification of currently unknown substrates for individual peptidases has a wider application to understanding mitochondrial diseases in general and the development of therapies for these incurable pathologies.

Activite de laboratoire

Research: a scientific adventure

Our goal: to better understand genetic diseases to better treat them.