The journal of experimental medicine 2021
Enhanced cGAS-STING-dependent interferon signaling associated with mutations ...
Publish at 18.11.2019
Yanick Crow is a clinician scientist, with the work of the Crow group driven by an interest in human diseases and a determination to improve their diagnosis and treatment.
Our work in this area started with the Mendelian inflammatory disorder Aicardi-Goutières syndrome (AGS). Clinical and genetic studies of this severe disease helped to define the phenotypic spectrum associated with mutations in the AGS-related genes, delineate a cell-intrinsic mechanism for the initiation of autoinflammation / autoimmunity by stimulatory nucleic acids, and further emphasise the importance of type I interferon processing in the pathogenesis of certain non-Mendelian disorders, particularly systemic lupus erythematosus. Since then, a combination of clinical, genetic and immunological perspectives has led us to suggest that monogenic disorders associated with an upregulation of type I interferons represent a novel set of inborn errors of immunity due to abnormal sensing, inappropriate stimulation, or defective negative regulation of the type I interferon system – the so-called type I interferonopathies. There is a clear unmet clinical need for treatments in this area, and the insights so far obtained suggest the possibility of therapies to block nucleic acid driven inflammation (for examples, see: Frémond et al. J Allergy Clin Immunol 2016;138:1752–1755; Kothur et al. Neurology 2018;90:289-291; Briand et al. Ann Rheum Dis 2019;78:431-433; Rice et al. N Engl J Med 2018;379:2275-2277), and have important implications for fundamental research into mechanisms of self / non-self discrimination and viral immunity.
chef d'équipe
Technician
Researcher (Inserm), PhD
MD, PhD
MD, PhD
Technician
Doctorant
PhD
PhD student
Master student
The journal of experimental medicine 2021
Enhanced cGAS-STING-dependent interferon signaling associated with mutations ...
Frontiers in immunology 2021
Mitochondrial Nucleic Acid as a Driver of Pathogenic Type I Interferon Induct...
Rheumatology (Oxford) 2021
Rheumatoid factor positive polyarticular juvenile idiopathic arthritis associ...
Nature genetics 2020
cGAS-mediated induction of type I interferon due to inborn errors of histone ...
Journal of Allergy Clinical Immunology: In practice 2020
Overview of STING-Associated Vasculopathy with Onset in Infancy (SAVI) Among ...
The journal of experimental medicine 2020
Mutations in COPA lead to abnormal trafficking of STING to the Golgi and inte...
Journal of allergy and clinical immunology 2020
The lancet rheumatology 2020
Contribution of rare and predicted pathogenic gene variants to childhood-onse...
The lancet neurology 2020
Neuromyelitis optica in patients with increased interferon alpha concentrations.
Journal of medical genetics 2019
Cardiac valve involvement in ADAR-related type I interferonopathy.
Rheumatology (Oxford) 2019
Anti-MDA5 juvenile idiopathic inflammatory myopathy: a specific subgroup defi...
Annual review of immunology 2019
Self-Awareness: Nucleic Acid-Driven Inflammation and the Type I Interferonopa...
The New England journal of medicine 2019
Reverse-Transcriptase Inhibitors in the Aicardi–Goutières Syndrome
Nature communications 2018
Type I interferon-mediated autoinflammation due to DNase II deficiency.
The journal of experimental medicine 2017
Detection of interferon alpha protein reveals differential levels and cellula...