Institut Imagine
Sigolène Meilhac
Morphogenèse du Cœur
Publié le
Présentation
Le laboratoire Imagine-Institut Pasteur de Morphogenèse du Coeur s'intéresse aux mécanismes embryonnaires de la formation du coeur. Nos recherches fondamentales dans le modèle murin ont des applications potentielles dans le domaine médical, pour les malformations congénitales et la réparation du cœur.
La forme d'un organe est étroitement liée à sa fonction. Pour le coeur, l'architecture du myocarde conditionne la fonction de contraction, et l'alignement des chambres cardiaques la double circulation sanguine.
Sans sculpteur ni ingénieur, comment les cellules s’assemblent-elles pour façonner un organe ? Comment connaissent-elles leurs positions relatives dans un tissu ? Comment leurs comportements sont-ils coordonnés au cours du développement embryonnaire pour générer une forme ?
Nous répondons à ces questions en utilisant des technologies de pointe en génétique, omiques, imagerie 3D, analyse quantitative de données complexes et simulations par ordinateur. Nous travaillons en étroite collaboration avec le Centre de Référence des Malformations Cardiaques Congénitales Complexes (M3C).
D'où vient l'asymétrie du coeur?
Equipe
Recrutement
Ressources & publications
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2025Journal (source)PLoS Biol
Notch3 is an asymmetric gene and a modifier of heart looping defects in Nodal...
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2023Journal (source)Dev Cell
Identification of Greb1l as a genetic determinant of crisscross heart in mice...
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Journal (source)Annu Rev Genomics Hum Genet
Heart Development and Congenital Structural Heart Defects.
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2020Journal (source)Dev Cell
Transient Nodal Signaling in Left Precursors Coordinates Opposed Asymmetries ...
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Journal (source)Philos Trans R Soc Lond B Biol Sci
Mesoderm patterning by a dynamic gradient of retinoic acid signalling.
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2020Journal (source)Cell Rep
Intraflagellar Transport Complex B Proteins Regulate the Hippo Effector Yap1 ...
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2019Journal (source)Dis Model Mech
Standardised imaging pipeline for phenotyping mouse laterality defects and as...
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2018Journal (source)Development
Left-right asymmetry in heart development and disease: forming the right loop.
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2018Journal (source)Nat Rev Cardiol
The deployment of cell lineages that form the mammalian heart.
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2017Journal (source)Elife
A predictive model of asymmetric morphogenesis from 3D reconstructions of mou...
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2017Journal (source)Am. J. Hum. Genet.
Mutations in GREB1L Cause Bilateral Kidney Agenesis in Humans and Mice.
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2017Journal (source)Nat Commun
Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 t...
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Journal (source)Cold Spring Harb Perspect Med
Cardiac cell lineages that form the heart.
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2015Journal (source)Cilia
The more we know, the more we have to discover: an exciting future for unders...
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Journal (source)Wiley Interdiscip Rev Syst Biol Med
Integrating multi-scale knowledge on cardiac development into a computational...
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2014Journal (source)Med Sci (Paris)
[Cilia and heart morphogenesis].
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2013Journal (source)Bioinformatics
Extracting 3D cell parameters from dense tissue environments: application to ...
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2013Journal (source)Dev. Dyn.
Resolving cell lineage contributions to the ventricular conduction system wit...
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2013Journal (source)Development
Quantitative analysis of polarity in 3D reveals local cell coordination in th...
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2012Journal (source)Circ. Res.
Lineage tree for the venous pole of the heart: clonal analysis clarifies cont...
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Journal (source)Results Probl Cell Differ
Cell lineages, growth and repair of the mouse heart.
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2011Journal (source)Dev. Cell
Tracing cells for tracking cell lineage and clonal behavior.
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2010Journal (source)Development
Clonal analysis reveals common lineage relationships between head muscles and...
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2010Journal (source)Circ. Res.
Biphasic development of the mammalian ventricular conduction system.
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2009Journal (source)Dev. Biol.
Active cell movements coupled to positional induction are involved in lineage...
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2009Journal (source)Circ. Res.
Landmarks and lineages in the developing heart.
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2008Journal (source)Dev. Biol.
Myocardium at the base of the aorta and pulmonary trunk is prefigured in the ...
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2007Journal (source)BMC Dev. Biol.
Regionalization of the mouse visceral endoderm as the blastocyst transforms i...
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2007Journal (source)Dev. Biol.
The anterior visceral endoderm of the mouse embryo is established from both p...
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2006Journal (source)Dev. Biol.
Left and right ventricular contributions to the formation of the interventric...
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2006Journal (source)Development
Smooth muscle of the dorsal aorta shares a common clonal origin with skeletal...
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2005Journal (source)Nat. Rev. Genet.
Building the mammalian heart from two sources of myocardial cells.
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2005Journal (source)Circ. Res.
Right ventricular myocardium derives from the anterior heart field.
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2004Journal (source)Dev. Cell
The clonal origin of myocardial cells in different regions of the embryonic m...
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2004Journal (source)J. Cell Biol.
Oriented clonal cell growth in the developing mouse myocardium underlies card...
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2003Journal (source)Development
A retrospective clonal analysis of the myocardium reveals two phases of clona...
La recherche : une aventure scientifique
Notre objectif : mieux comprendre les maladies génétiques pour mieux les soigner.
Chiifres clé
34 publications
