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Alain Fischer est l’un des membres fondateurs d’Imagine. Après avoir passé son diplôme de médecine avec Claude Griscelli, il est nommé professeur d’immunologie, puis directeur de l’unité Inserm « Développement normal et pathologique du système immunitaire », en 1991. De 1996 à 2012, il est est chef de l'unité Immunologie et hématologie pédiatriques de l’hôpital Necker-Enfants malades.
Il est membre de l’académie des sciences et titulaire de la chaire de médecine expérimentale au Collège de France.
Les travaux d'Alain Fischer portent depuis des années sur les déficits immunitaires acquis dès la naissance et le développement de stratégie comme la thérapie génique.
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Ressources & publications
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      2017Journal (source)J Allergy Clin ImmunolClinical spectrum and features of activated phosphoinositide 3-kinase δ syndr...
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      2020Journal (source)Nat CommunKinesin-1 regulates antigen cross-presentation through the scission of tubula...
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      2020Journal (source)ScienceImpaired type I interferon activity and inflammatory responses in severe COVI...
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      2020Journal (source)JCI InsightImpaired lymphocyte function and differentiation in CTPS1-deficient patients ...
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      2019Journal (source)J. Exp. Med.Concomitant PIK3CD and TNFRSF9 deficiencies cause chronic active Epstein-Barr...
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      2019Journal (source)Immunol. Rev.Signaling pathways involved in the T-cell-mediated immunity against Epstein-B...
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      2020Journal (source)ScienceImpaired type I interferon activity and inflammatory responses in severe COVI...
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      2020Journal (source)Nat CommunEarly-onset autoimmunity associated with SOCS1 haploinsufficiency.
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      2020Journal (source)BloodClonal tracking in gene therapy patients reveals a diversity of human hematop...
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      2021Journal (source)J Allergy Clin ImmunolImproving the diagnostic efficiency of primary immunodeficiencies with target...
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      2018Journal (source)Front ImmunolDisease Evolution and Response to Rapamycin in Activated Phosphoinositide 3-K...
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      2020Journal (source)Blood AdvEfficacy of ruxolitinib in subcutaneous panniculitis-like T-cell lymphoma and...
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      2020Journal (source)BloodTopoisomerase 2β mutation impairs early B-cell development.
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      Journal (source)Mol Ther Methods Clin DevBiosafety Studies of a Clinically Applicable Lentiviral Vector for the Gene T...
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      2018Journal (source)Front ImmunolDisease Evolution and Response to Rapamycin in Activated Phosphoinositide 3-K...
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      2021Journal (source)J Allergy Clin ImmunolImproving the diagnostic efficiency of primary immunodeficiencies with target...
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      2017Journal (source)BloodReticular dysgenesis: international survey on clinical presentation, transpla...
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      2015Journal (source)J Allergy Clin ImmunolAn in vivo genetic reversion highlights the crucial role of Myb-Like, SWIRM, ...
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      2015Journal (source)JAMAOutcomes following gene therapy in patients with severe Wiskott-Aldrich syndr...
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      Journal (source)Proc Natl Acad Sci U S AAlternative pathways for the development of lymphoid structures in humans.
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      2021Journal (source)Med (N Y)A monocyte/dendritic cell molecular signature of SARS-CoV-2-related multisyst...
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      Journal (source)Journal of Allergy and Clinical ImmunologyRab44 regulates murine mast cell–driven anaphylaxis through kinesin-1–depende...
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      2015Journal (source)F1000ResCytotoxic granule secretion by lymphocytes and its link to immune homeostasis.
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      2019Journal (source)Nat. Rev. Genet.Somatic genetic rescue in Mendelian haematopoietic diseases.
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      2019Journal (source)BloodPediatric Evans syndrome is associated with a high frequency of potentially d...
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      2019Journal (source)Front ImmunolChronic Intestinal Pseudo-Obstruction and Lymphoproliferative Syndrome as a N...
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      2018Journal (source)Hum. Mutat.A RAB27A duplication in several cases of Griscelli syndrome type 2: An explan...
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      2017Journal (source)BloodTherapeutic effect of JAK1/2 blockade on the manifestations of hemophagocytic...
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      Journal (source)Arterioscler. Thromb. Vasc. Biol.Kinesin-1 Is a New Actor Involved in Platelet Secretion and Thrombus Stability.
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      2017Journal (source)J. Cell Biol.Kinesin-1 controls mast cell degranulation and anaphylaxis through PI3K-depen...
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      2012Journal (source)BloodTerminal transport of lytic granules to the immune synapse is mediated by the...
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      2013Journal (source)BloodDistinct severity of HLH in both human and murine mutants with complete loss ...
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      2015Journal (source)TrafficLYST controls the biogenesis of the endosomal compartment required for secret...
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      2020Journal (source)HaematologicaTtc7a regulates hematopoietic stem cell functions while controlling the stres...
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      2017Journal (source)BloodPolygenic mutations in the cytotoxicity pathway increase susceptibility to de...
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      2015Journal (source)BloodA novel immunoregulatory role for NK-cell cytotoxicity in protection from HLH...
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      2019Journal (source)Nat. Genet.Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculit...
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      2019Journal (source)J. Clin. Invest.Loss of ARHGEF1 causes a human primary antibody deficiency.
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      2018Journal (source)HaematologicaMutations in the adaptor-binding domain and associated linker region of p110δ...
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      Journal (source)J. Allergy Clin. Immunol. 2017Clinical and immunologic phenotype associated with activated phosphoinositide...
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      2015Journal (source)J. Clin. Invest.A human immunodeficiency caused by mutations in the PIK3R1 gene.
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      Journal (source)J. Allergy Clin. Immunol.X-linked primary immunodeficiency associated with hemizygous mutations in the...
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      2016Journal (source)Cell Death DisAK2 deficiency compromises the mitochondrial energy metabolism required for d...
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      2006Journal (source)N. Engl. J. Med.Inherited and somatic CD3zeta mutations in a patient with T-cell deficiency.