Annarita MICCIO | Institut Imagine

Présentation

Lab Director-Group Leader

Annarita MICCIO

Chromatine et régulation génique au cours du développement

Contact :

01 42 75 43 34

annarita.miccio@institutimagine.org

À propos

Publications scientifiques

Publications

2026

Enhanced γ-globin reactivation and sickle cell correction through a repressor..., Mol Ther Nucleic Acids
2026

CleanFinder: a scalable framework for comprehensive genome editing analysis., Trends Biotechnol
2025

Base editing of β-thalassemia mutations as a therapeutic strategy for severe ..., Sci Transl Med
2025

VEXAS anemia is a mosaic erythroblastopenia., Blood
2025

A prime editing strategy to rewrite the γ-globin promoters and reactivate fet..., Blood
2025

Dissecting the epigenetic regulation of the fetal hemoglobin genes to unravel..., Nucleic Acids Res
2025

Severe inflammation and lineage skewing are associated with poor engraftment ..., Nat Commun
2024

Safety and efficacy studies of CRISPR-Cas9 treatment of sickle cell disease h..., Mol Ther
2024

Revolutionising healing: Gene Editing's breakthrough against sickle cell dise..., Blood Rev
2023

Novel lentiviral vectors for gene therapy of sickle cell disease combining ge..., Mol Ther Nucleic Acids
2022

Adenine base editor-mediated correction of the common and severe IVS1-110 (G>..., Blood
2022

Base-editing-mediated dissection of a γ-globin cis-regulatory element for the..., Nat Commun
2022

Long-term outcomes of lentiviral gene therapy for the β-hemoglobinopathies: t..., Nat Med
2021

Fetal hemoglobin rescues ineffective erythropoiesis in sickle cell disease., Haematologica
2021

Novel genome-editing-based approaches to treat motor neuron diseases: Promise..., Mol Ther
2021

Genome editing approaches to β-hemoglobinopathies., Prog Mol Biol Transl Sci
2020

GATA Factor-Mediated Gene Regulation in Human Erythropoiesis., iScience
2020

Editing a γ-globin repressor binding site restores fetal hemoglobin synthesis..., Sci Adv
2019

GATA factor transcriptional activity: Insights from genome-wide binding profi..., IUBMB Life
2019

Extensive multilineage analysis in patients with mixed chimerism after alloge..., Haematologica
2019

Lentiviral and genome-editing strategies for the treatment of β-hemoglobinopa..., Blood
2019

Gene therapy of hemoglobinopathies: progress and future challenges., Hum Mol Genet
2019

Gene therapy targeting haematopoietic stem cells for inherited diseases: prog..., Nat Rev Drug Discov
2018

Optimization of CRISPR/Cas9 Delivery to Human Hematopoietic Stem and Progenit..., Mol Ther
2018

An Optimized Lentiviral Vector Efficiently Corrects the Human Sickle Cell Dis..., Mol Ther Methods Clin Dev
2018

Induction of fetal hemoglobin synthesis by CRISPR/Cas9-mediated editing of th..., Blood
2018

Plerixafor enables safe, rapid, efficient mobilization of hematopoietic stem ..., Haematologica
2017

Concise Review: Epigenetic Regulation of Hematopoiesis: Biological Insights a..., Stem Cells Transl Med
2016

Transcriptional, epigenetic and retroviral signatures identify regulatory reg..., Sci Rep
2016

Dynamic Transcriptional and Epigenetic Regulation of Human Epidermal Keratino..., Stem Cell Reports
2015

Genome-Wide Definition of Promoter and Enhancer Usage during Neural Induction..., PLoS One
2013

Nup153 and Nup98 bind the HIV-1 core and contribute to the early steps of HIV..., Virology
2013

Deletion of the LTR enhancer/promoter has no impact on the integration profil..., PLoS One
2012

Lentiviral vector integration in the human genome induces alternative splicin..., J Clin Invest
2011

The GATA1-HS2 enhancer allows persistent and position-independent expression ..., PLoS One
2010

Role of the GATA-1/FOG-1/NuRD pathway in the expression of human beta-like gl..., Mol Cell Biol
2010

FOG1 requires NuRD to promote hematopoiesis and maintain lineage fidelity wit..., Blood
2009

NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during ..., EMBO J
2009

Transcription factor binding sites are genetic determinants of retroviral int..., PLoS One
2008

In vivo selection of genetically modified erythroblastic progenitors leads to..., Proc Natl Acad Sci U S A
2007

The homeodomain transcription factor Prep1 (pKnox1) is required for hematopoi..., Dev Biol
2007

Hot spots of retroviral integration in human CD34+ hematopoietic cells., Blood
2006

Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction..., Mol Cell Biol
2005

Phosphorylation of synapsin I by cAMP-dependent protein kinase controls synap..., J Neurosci

Présentation

À propos

Publications scientifiques

Enhanced γ-globin reactivation and sickle cell correction through a repressor..., Mol Ther Nucleic Acids

CleanFinder: a scalable framework for comprehensive genome editing analysis., Trends Biotechnol

Base editing of β-thalassemia mutations as a therapeutic strategy for severe ..., Sci Transl Med

VEXAS anemia is a mosaic erythroblastopenia., Blood

A prime editing strategy to rewrite the γ-globin promoters and reactivate fet..., Blood

Dissecting the epigenetic regulation of the fetal hemoglobin genes to unravel..., Nucleic Acids Res

Severe inflammation and lineage skewing are associated with poor engraftment ..., Nat Commun

Safety and efficacy studies of CRISPR-Cas9 treatment of sickle cell disease h..., Mol Ther

Revolutionising healing: Gene Editing's breakthrough against sickle cell dise..., Blood Rev

Novel lentiviral vectors for gene therapy of sickle cell disease combining ge..., Mol Ther Nucleic Acids

Adenine base editor-mediated correction of the common and severe IVS1-110 (G>..., Blood

Base-editing-mediated dissection of a γ-globin cis-regulatory element for the..., Nat Commun

Long-term outcomes of lentiviral gene therapy for the β-hemoglobinopathies: t..., Nat Med

Fetal hemoglobin rescues ineffective erythropoiesis in sickle cell disease., Haematologica

Novel genome-editing-based approaches to treat motor neuron diseases: Promise..., Mol Ther

Genome editing approaches to β-hemoglobinopathies., Prog Mol Biol Transl Sci

GATA Factor-Mediated Gene Regulation in Human Erythropoiesis., iScience

Editing a γ-globin repressor binding site restores fetal hemoglobin synthesis..., Sci Adv

GATA factor transcriptional activity: Insights from genome-wide binding profi..., IUBMB Life

Extensive multilineage analysis in patients with mixed chimerism after alloge..., Haematologica

Lentiviral and genome-editing strategies for the treatment of β-hemoglobinopa..., Blood

Gene therapy of hemoglobinopathies: progress and future challenges., Hum Mol Genet

Gene therapy targeting haematopoietic stem cells for inherited diseases: prog..., Nat Rev Drug Discov

Optimization of CRISPR/Cas9 Delivery to Human Hematopoietic Stem and Progenit..., Mol Ther

An Optimized Lentiviral Vector Efficiently Corrects the Human Sickle Cell Dis..., Mol Ther Methods Clin Dev

Induction of fetal hemoglobin synthesis by CRISPR/Cas9-mediated editing of th..., Blood

Plerixafor enables safe, rapid, efficient mobilization of hematopoietic stem ..., Haematologica

Concise Review: Epigenetic Regulation of Hematopoiesis: Biological Insights a..., Stem Cells Transl Med

Transcriptional, epigenetic and retroviral signatures identify regulatory reg..., Sci Rep

Dynamic Transcriptional and Epigenetic Regulation of Human Epidermal Keratino..., Stem Cell Reports

Genome-Wide Definition of Promoter and Enhancer Usage during Neural Induction..., PLoS One

Nup153 and Nup98 bind the HIV-1 core and contribute to the early steps of HIV..., Virology

Deletion of the LTR enhancer/promoter has no impact on the integration profil..., PLoS One

Lentiviral vector integration in the human genome induces alternative splicin..., J Clin Invest

The GATA1-HS2 enhancer allows persistent and position-independent expression ..., PLoS One

Role of the GATA-1/FOG-1/NuRD pathway in the expression of human beta-like gl..., Mol Cell Biol

FOG1 requires NuRD to promote hematopoiesis and maintain lineage fidelity wit..., Blood

NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during ..., EMBO J

Transcription factor binding sites are genetic determinants of retroviral int..., PLoS One

In vivo selection of genetically modified erythroblastic progenitors leads to..., Proc Natl Acad Sci U S A

The homeodomain transcription factor Prep1 (pKnox1) is required for hematopoi..., Dev Biol

Hot spots of retroviral integration in human CD34+ hematopoietic cells., Blood

Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction..., Mol Cell Biol

Phosphorylation of synapsin I by cAMP-dependent protein kinase controls synap..., J Neurosci